HDBase – A Community Website for Huntington’s Disease Research
Welcome to the future home of HDBase, a community website for Huntington’s Disease (HD) research. The purpose of HDBase is to collect and present information that will assist HD researchers in their work. Content areas that may be covered by the site include the following:
- Therapeutic studies in mouse, primarily drug screens.
- HD mouse models with a focus on timelines of disease progression.
- Antibodies used in HD research.
- Microarray gene expression studies.
- Genes and proteins relevant to HD research. This includes HD itself, the growing list of proteins thought to interact directly or indirectly with huntingtin (Htt), and other genes and proteins implicated in the disease process.
- Molecular pathways thought to be involved in the disease process.
- Timelines of disease for Mouse models
Presently, we have Y2H and Mass Spec. protein-protein interaction data centered around the HD protein (huntingtin) and information on therapeutic studies in mouse. We also have Human and Mouse Affymetrix Microarray data.
- THC cleansing kits explained: how fast they act, what they really do, and how to choose
- Facing a urine test for marijuana: timelines, risks, and safer choices you can make
- Whizzinator claims under DOT rules: a sober guide for CDL drivers who are tempted to try
- TestClear Urine Reviews: Does Powdered Human Urine Really Work and How to Heat It Right?
- Monkey Whizz review: reliability, concealability, and detection risk explained for 2025
- How to pass a drug test for probation safely and realistically
- Certo Detox, Gatorade, and Urine Tests: A cautious, side‑by‑side look at what really helps
- Oral Clear Chewing Gum Review for CDL Drivers: Claims, Risks, and Practical Takeaways
- How to pass a mouth swab fast without risky moves: a practical, product‑aware cheat sheet
- Incognito Belt Urine Kit Review and Advanced Use Guide for Risk‑Aware Buyers
- High Voltage Detox Shampoo Review: A careful, comparison-first look at whether it can help you pass a hair test
- Looking for a drink to pass a drug test? Here’s how these products really work and how to use them safely
- Macujo Method Steps: A Cautious, Practical Framework for Hair Drug Test Prep
- Quick Fix Synthetic Urine in 2025: a careful review, real‑world comparisons, and a step‑by‑step setup for lawful demos
- Sub Solution Synthetic Urine in 2025: A cautious review, risk checklist, and buyer awareness guide
The protein interaction data is from several sources, including interactions curated from the literature by ISB staff, experimentally determined interactions produced by Bob Hughes and colleagues at Prolexys (currently password protected, sorry — will be public when the manuscript is published), and interactions reported in a recent publication by Goehler et al from Eric Wanker’s lab.
HDBase is funded by the Hereditary Disease Foundation. The site is developed and operated by the Institute for Systems Biology in association with the Alzheimer Research Forum. HDBase makes extensive use of software developed by the JDRF Center for Bioinformatics, a project funded by the Juvenile Diabetes Research Foundation to create a community website for type 1 diabetes research.
We welcome your comments. Please email us at [email protected].