Mouse Therapeutic Studies

This content area includes all studies that apply any kind of treatment to living whole mice, and that measure efficacy. We define treatment to mean any intervention, even ones that could not plausibly be used as human therapies, to avoid disputes about the practicality of any particular treatment. We define efficacy to mean any property of the animal that has a reasonably clear connection to disease progression or severity.

The content area excludes human trials, studies of non-mouse models, and studies done on cells, brain slices, or other systems that are not whole animals. It excludes studies of genetic effects, e.g., crosses of HD mice with other strains, on the grounds that these are studies of molecular mechanism rather than treatments. It also excludes studies in which the only measurements are molecular on the grounds that these are studies of molecular mechanism rather than efficacy.

Legend and Notes

• Each row in the table represents one study reported in the given reference: a particular drug or treatment applied to a particular mouse model at a given dosage and route of administration.
• The icon  indicates that additional information is available by clicking on the icon.
• In a few cases, we converted actual doses (expressed, e.g., as mg per liter of drinking water) to nominal dose (expressed as mg per kg of body mass) using standard formulas.
• The start column tells when the drug or treatment was begun. Times are generally in weeks postpartum.
• The remaining columns report outcome measures. A green + indicates that the paper reports an improvement in that measure; in most cases, we only include outcomes that are described in the paper as being statistically significant; in a few cases, we include outcomes that are near significance or described as being important. A yellow ~ indicates that the paper reports that the measurement was performed, and no significant (or important) improvement was found. A red – indicates that the paper reports that the measurement was performed, and was found to be worse than in the control. A blank indicates that no measurement was reported.
• Some columns, e.g., ‘Atrophy’, report outcomes from a variety of tests of a general category. The notation is test name followed by ‘+’, ‘~’, or ‘-‘. The absence of a test name indicates that the paper reported no outcome for the test.
• Note that for some outcomes, an improvement implies that the measure gets bigger, e.g., for survival, while for others the measure gets smaller, e.g., for aggregates.
• The diabetes column indicates measurements that pertain to diabetic complications often seen in these mouse models.

Table